Proteasome inhibition with bortezomib (PS-341): a phase I study with pharmacodynamic end points using a day 1 and day 4 schedule in a 14-day cycle.

Hamilton, A L; Eder, J P; Pavlick, A C; Clark, J W; Liebes, L; Garcia-Carbonero, R; Chachoua, A; Ryan, D P; Soma, V; Farrell, K; Kinchla, N; Boyden, J; Yee, H; Zeleniuch-Jacquotte, A; Wright, J; Elliott, P; Adams, J; Muggia, F M

Hamilton, A L; Eder, J P; Pavlick, A C; Clark, J W; Liebes, L; Garcia-Carbonero, R; Chachoua, A; Ryan, D P; Soma, V; Farrell, K; Kinchla, N; Boyden, J; Yee, H; Zeleniuch-Jacquotte, A; Wright, J; Elliott, P; Adams, J; Muggia, F M.

Affiliation

Hamilton AL; New York University School of Medicine, New York, NY, USA.

J Clin Oncol ; 23(25): 6107-16, 2005 Sep 01.

Article in En | MEDLINE | ID: mdl-16135477

Subject(s)

Antineoplastic Agents/pharmacology; Antineoplastic Agents/pharmacokinetics; Boronic Acids/pharmacology; Boronic Acids/pharmacokinetics; Pyrazines/pharmacology; Pyrazines/pharmacokinetics; Adult; Aged; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/therapeutic use; Boronic Acids/administration & dosage; Boronic Acids/therapeutic use; Bortezomib; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Lymphoma/drug therapy; Male; Middle Aged; Neoplasms/drug therapy; Peripheral Nervous System/drug effects; Peripheral Nervous System/pathology; Proteasome Endopeptidase Complex/blood; Proteasome Inhibitors; Pyrazines/administration & dosage; Pyrazines/therapeutic use; Treatment Outcome

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Database: MEDLINE Main subject: Pyrazines / Boronic Acids / Antineoplastic Agents Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Year: 2005 Type: Article

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