Improved effector functions of a therapeutic monoclonal Lewis Y-specific antibody by glycoform engineering.

Schuster, Manfred; Umana, Pablo; Ferrara, Claudia; Brünker, Peter; Gerdes, Christian; Waxenecker, Günter; Wiederkum, Susanne; Schwager, Cornelia; Loibner, Hans; Himmler, Gottfried; Mudde, Geert C

Schuster, Manfred; Umana, Pablo; Ferrara, Claudia; Brünker, Peter; Gerdes, Christian; Waxenecker, Günter; Wiederkum, Susanne; Schwager, Cornelia; Loibner, Hans; Himmler, Gottfried; Mudde, Geert C.

Affiliation

Schuster M; igeneon AG, Brunnerstrasse, Vienna, Austria. manfred.schuster@igeneon.com

Cancer Res ; 65(17): 7934-41, 2005 Sep 01.

Article in En | MEDLINE | ID: mdl-16140965

Subject(s)

Antibodies, Monoclonal/immunology; Lewis Blood Group Antigens/immunology; Oligosaccharides/metabolism; Antibodies, Monoclonal/biosynthesis; Antibodies, Monoclonal/genetics; Antibody Specificity; Antibody-Dependent Cell Cytotoxicity; Cell Line, Tumor; Glycosylation; Humans; Immunoglobulin G/biosynthesis; Immunoglobulin G/genetics; Immunoglobulin G/immunology; Mannosidases/genetics; Mannosidases/metabolism; N-Acetylglucosaminyltransferases/genetics; N-Acetylglucosaminyltransferases/metabolism; Neoplasms/immunology; Neoplasms/therapy; Oligosaccharides/immunology; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transfection

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Database: MEDLINE Main subject: Oligosaccharides / Lewis Blood Group Antigens / Antibodies, Monoclonal Limits: Humans Language: En Year: 2005 Type: Article

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PubMed Links

Database: MEDLINE Main subject: Oligosaccharides / Lewis Blood Group Antigens / Antibodies, Monoclonal Limits: Humans Language: En Year: 2005 Type: Article