A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension.

Liu, Songling; Premont, Richard T; Kontos, Christopher D; Zhu, Shoukang; Rockey, Don C

Liu, Songling; Premont, Richard T; Kontos, Christopher D; Zhu, Shoukang; Rockey, Don C.

Affiliation

Liu S; Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

Nat Med ; 11(9): 952-8, 2005 Sep.

Article in En | MEDLINE | ID: mdl-16142243

Subject(s)

Cyclic AMP-Dependent Protein Kinases/physiology; Endothelial Cells/enzymology; Hypertension, Portal/metabolism; Nitric Oxide Synthase/metabolism; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/metabolism; Animals; Cells, Cultured; G-Protein-Coupled Receptor Kinase 2; Isoenzymes; Male; Nitric Oxide; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; beta-Adrenergic Receptor Kinases

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Database: MEDLINE Main subject: Proto-Oncogene Proteins / Protein Serine-Threonine Kinases / Cyclic AMP-Dependent Protein Kinases / Nitric Oxide Synthase / Endothelial Cells / Hypertension, Portal Limits: Animals Language: En Year: 2005 Type: Article

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