GATA1-mediated megakaryocyte differentiation and growth control can be uncoupled and mapped to different domains in GATA1.

Kuhl, Christiane; Atzberger, Ann; Iborra, Francisco; Nieswandt, Bernhard; Porcher, Catherine; Vyas, Paresh

Kuhl, Christiane; Atzberger, Ann; Iborra, Francisco; Nieswandt, Bernhard; Porcher, Catherine; Vyas, Paresh.

Affiliation

Kuhl C; Department of Hematology, Weatherall Institute of Molecular Medicine, University of Oxford and John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom.

Mol Cell Biol ; 25(19): 8592-606, 2005 Oct.

Article in En | MEDLINE | ID: mdl-16166640

Subject(s)

GATA1 Transcription Factor/physiology; Megakaryocytes/cytology; Amino Acid Sequence; Animals; Antigens, CD/biosynthesis; Blood Platelets/metabolism; Blotting, Western; Cell Differentiation; Cell Line; Cell Proliferation; Cell Separation; Chickens; Cloning, Molecular; DNA/chemistry; Flow Cytometry; GATA1 Transcription Factor/chemistry; GATA1 Transcription Factor/metabolism; Green Fluorescent Proteins/metabolism; Megakaryocytes/metabolism; Membrane Glycoproteins/biosynthesis; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Models, Genetic; Molecular Sequence Data; Mutation; Phenotype; Platelet Membrane Glycoprotein IIb/biosynthesis; Protein Binding; Protein Structure, Tertiary; Retroviridae/genetics; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Stem Cells/cytology; Tetraspanin 29; Zinc Fingers

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Full text: 1 Database: MEDLINE Main subject: Megakaryocytes / GATA1 Transcription Factor Type of study: Prognostic_studies Language: En Year: 2005 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Megakaryocytes / GATA1 Transcription Factor Type of study: Prognostic_studies Language: En Year: 2005 Type: Article