A teleost in vitro reporter gene assay to screen for agonists of the peroxisome proliferator-activated receptors.

Liu, Gele; Moon, Thomas W; Metcalfe, Chris D; Lee, Lucy E J; Trudeau, Vance L

Liu, Gele; Moon, Thomas W; Metcalfe, Chris D; Lee, Lucy E J; Trudeau, Vance L.

Affiliation

Liu G; Centre for Advanced Research in Environmental Genomics and Department of Biology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada.

Environ Toxicol Chem ; 24(9): 2260-6, 2005 Sep.

Article in En | MEDLINE | ID: mdl-16193754

Subject(s)

Environmental Monitoring/methods; Peroxisome Proliferator-Activated Receptors/agonists; Acetyl-CoA C-Acyltransferase/genetics; Alitretinoin; Angiogenesis Inhibitors/pharmacology; Animals; Bezafibrate/pharmacology; Cloning, Molecular; DNA/metabolism; DNA, Complementary/metabolism; Dose-Response Relationship, Drug; Gemfibrozil/pharmacology; Genes, Reporter; Humans; Hypolipidemic Agents/pharmacology; In Vitro Techniques; Liver/enzymology; Luciferases/metabolism; Oncorhynchus mykiss; PPAR alpha/genetics; PPAR-beta/genetics; Peroxisome Proliferators/pharmacology; Plasmids/metabolism; Promoter Regions, Genetic; Pyrimidines/pharmacology; Rats; Retinoid X Receptors/metabolism; Transcription, Genetic; Transfection; Tretinoin/pharmacology; Water Pollutants, Chemical/analysis

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Database: MEDLINE Main subject: Environmental Monitoring / Peroxisome Proliferator-Activated Receptors Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2005 Type: Article

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