IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes.

Smart, Nicola; Mojet, Mart H; Latchman, David S; Marber, Michael S; Duchen, Michael R; Heads, Richard J

Smart, Nicola; Mojet, Mart H; Latchman, David S; Marber, Michael S; Duchen, Michael R; Heads, Richard J.

Affiliation

Smart N; Cardiovascular Division, King's College London School of Medicine, Department of Cardiology, The Rayne Institute, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK.

Cardiovasc Res ; 69(1): 164-77, 2006 Jan.

Article in En | MEDLINE | ID: mdl-16219301

Subject(s)

Interleukin-6/pharmacology; Mitochondria, Heart/metabolism; Myocardial Reperfusion Injury/prevention & control; Myocytes, Cardiac/metabolism; Nitric Oxide/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Androstadienes/pharmacology; Animals; Calcium/metabolism; Cells, Cultured; Cytosol/metabolism; Enzyme Inhibitors/pharmacology; Membrane Potentials/drug effects; Microscopy, Confocal; Myocardial Reperfusion Injury/metabolism; Myocardial Reperfusion Injury/pathology; Nitric Oxide Synthase Type II/metabolism; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum/metabolism; Wortmannin

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Database: MEDLINE Main subject: Myocardial Reperfusion Injury / Interleukin-6 / Phosphatidylinositol 3-Kinases / Myocytes, Cardiac / Mitochondria, Heart / Nitric Oxide Type of study: Prognostic_studies Limits: Animals Language: En Year: 2006 Type: Article

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