Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells.

Zhang, Hua; Chua, Kevin S; Guimond, Martin; Kapoor, Veena; Brown, Margaret V; Fleisher, Thomas A; Long, Lauren M; Bernstein, Donna; Hill, Brenna J; Douek, Daniel C; Berzofsky, Jay A; Carter, Charles S; Read, E J; Helman, Lee J; Mackall, Crystal L

Zhang, Hua; Chua, Kevin S; Guimond, Martin; Kapoor, Veena; Brown, Margaret V; Fleisher, Thomas A; Long, Lauren M; Bernstein, Donna; Hill, Brenna J; Douek, Daniel C; Berzofsky, Jay A; Carter, Charles S; Read, E J; Helman, Lee J; Mackall, Crystal L.

Affiliation

Zhang H; Pediatric Oncology Branch, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA.

Nat Med ; 11(11): 1238-43, 2005 Nov.

Article in En | MEDLINE | ID: mdl-16227988

Subject(s)

CD4-Positive T-Lymphocytes/drug effects; Interleukin-2/therapeutic use; Lymphopenia/drug therapy; Receptors, Interleukin-2/immunology; T-Lymphocytes, Regulatory/drug effects; Adolescent; Adult; Animals; CD4-Positive T-Lymphocytes/immunology; Child; Female; Forkhead Transcription Factors/analysis; Homeostasis/immunology; Humans; Interleukin-2/administration & dosage; Interleukin-2/immunology; Lymphocyte Transfusion; Lymphopenia/chemically induced; Lymphopenia/immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Receptors, Interleukin-2/metabolism; Recombinant Proteins/therapeutic use; Sarcoma/complications; Sarcoma/drug therapy; T-Lymphocytes, Regulatory/immunology

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Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / Receptors, Interleukin-2 / Interleukin-2 / T-Lymphocytes, Regulatory / Lymphopenia Limits: Adolescent / Adult / Animals / Child / Female / Humans / Middle aged Language: En Year: 2005 Type: Article

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