Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4+ T lymphocytes.

Naarding, Marloes A; Ludwig, Irene S; Groot, Fedde; Berkhout, Ben; Geijtenbeek, Teunis B H; Pollakis, Georgios; Paxton, William A

Naarding, Marloes A; Ludwig, Irene S; Groot, Fedde; Berkhout, Ben; Geijtenbeek, Teunis B H; Pollakis, Georgios; Paxton, William A.

Affiliation

Naarding MA; Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

J Clin Invest ; 115(11): 3256-64, 2005 Nov.

Article in En | MEDLINE | ID: mdl-16239964

Subject(s)

CD4-Positive T-Lymphocytes/virology; Cell Adhesion Molecules/metabolism; HIV Infections/immunology; HIV Infections/prevention & control; HIV-1/immunology; Lectins, C-Type/metabolism; Lewis X Antigen/metabolism; Milk, Human/immunology; Milk, Human/metabolism; Receptors, Cell Surface/metabolism; Trisaccharides/metabolism; CD4-Positive T-Lymphocytes/immunology; Cell Adhesion Molecules/physiology; Cell Line, Tumor; Cells, Cultured; Dendritic Cells/immunology; Dendritic Cells/virology; Female; HIV Infections/transmission; Humans; Infectious Disease Transmission, Vertical; Lectins, C-Type/physiology; Lewis X Antigen/physiology; Protein Binding/immunology; Receptors, Cell Surface/physiology; Trisaccharides/physiology

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Full text: 1 Database: MEDLINE Main subject: Trisaccharides / CD4-Positive T-Lymphocytes / Cell Adhesion Molecules / HIV Infections / Lewis X Antigen / HIV-1 / Receptors, Cell Surface / Lectins, C-Type / Milk, Human Limits: Female / Humans Language: En Year: 2005 Type: Article

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