Inhibition of prohormone convertase 1 (PC1) expression in cholecystokinin (CCK) expressing At-T20 cells decreased cellular content and secretion of CCK and caused a shift in molecular forms of CCK secreted.

Beinfeld, Margery C; Vishnuvardhan, Daesety; Blum, Alissa; Reynolds, Nicole; Fannous, Sanya; Kitagawa, Kouki; Marchand, James E

Beinfeld, Margery C; Vishnuvardhan, Daesety; Blum, Alissa; Reynolds, Nicole; Fannous, Sanya; Kitagawa, Kouki; Marchand, James E.

Affiliation

Beinfeld MC; Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.

Peptides ; 27(4): 905-10, 2006 Apr.

Article in En | MEDLINE | ID: mdl-16274843

Subject(s)

Cholecystokinin/chemistry; Cholecystokinin/metabolism; Gene Expression; Proprotein Convertase 1/deficiency; Amino Acid Sequence; Animals; Cell Line; Gene Expression/drug effects; Mice; Molecular Sequence Data; Proprotein Convertase 1/biosynthesis; Proprotein Convertase 1/genetics; Protein Isoforms/chemistry; Protein Isoforms/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Rats

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Cholecystokinin / Gene Expression / Proprotein Convertase 1 Limits: Animals Language: En Year: 2006 Type: Article

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Cholecystokinin / Gene Expression / Proprotein Convertase 1 Limits: Animals Language: En Year: 2006 Type: Article