A LC-MS/MS method to quantify the novel cholesterol lowering drug ezetimibe in human serum, urine and feces in healthy subjects genotyped for SLCO1B1.

Oswald, Stefan; Scheuch, Eberhard; Cascorbi, Ingolf; Siegmund, Werner

Oswald, Stefan; Scheuch, Eberhard; Cascorbi, Ingolf; Siegmund, Werner.

Affiliation

Oswald S; Department of Clinical Pharmacology of the Peter Holtz Research Center of Pharmacology and Experimental Therapeutics, University of Greifswald, Germany. stefan.oswald@uni-greifswald.de

J Chromatogr B Analyt Technol Biomed Life Sci ; 830(1): 143-50, 2006 Jan 02.

Article in En | MEDLINE | ID: mdl-16280261

Subject(s)

Anticholesteremic Agents/pharmacokinetics; Azetidines/pharmacokinetics; Chromatography, Liquid/methods; Feces/chemistry; Mass Spectrometry/methods; Organic Anion Transporters/genetics; Adult; Anticholesteremic Agents/blood; Anticholesteremic Agents/urine; Azetidines/blood; Azetidines/urine; Base Sequence; DNA Primers; Ezetimibe; Genotype; Humans; Liver-Specific Organic Anion Transporter 1; Male; Reference Standards; Reference Values

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Database: MEDLINE Main subject: Mass Spectrometry / Azetidines / Chromatography, Liquid / Organic Anion Transporters / Feces / Anticholesteremic Agents Limits: Adult / Humans / Male Language: En Year: 2006 Type: Article

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