The threshold of the intermittent hypoxic exposure period to elicit polycythemia in rats.
Tokai J Exp Clin Med
; 30(3): 157-61, 2005 Sep.
Article
in En
| MEDLINE
| ID: mdl-16285606
ABSTRACT
It is not yet clear whether there is an intermittent hypoxia (IHx) threshold to elicit polycythemia and blood pressure elevation, and whether blood hemoglobin concentration ([Hb]) increases with an increase in the hypoxic exposure period. We have previously shown that repetitive exposure to 10% O2 for 60 min/day for up to 5 weeks does not produce polycythemia. In the present study, we evaluated the effect of IHx of 10% O2, 120 min/day for 1, 2, 3 and 4 weeks on [Hb], arterial blood pressure, heart rate and arterial blood gases in the rat. IHx of 10% O2, 120 min/day induced polycythemia at 1 week and produced a time-dependent increase in [Hb] from 0 week to 4 weeks. Arterial blood pressure significantly increased during IHx exposure for 4 weeks probably due to a combination of an increased sympathetic activity as well as increased blood viscosity. The IHx threshold for polycythemia might exist between 60 min/day and 120 min/day in this level of hypoxia.
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Database:
MEDLINE
Main subject:
Polycythemia
/
Hypoxia
Limits:
Animals
Language:
En
Year:
2005
Type:
Article