Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1-dependent microvascular degeneration.

Kermorvant-Duchemin, Elsa; Sennlaub, Florian; Sirinyan, Mirna; Brault, Sonia; Andelfinger, Gregor; Kooli, Amna; Germain, Stéphane; Ong, Huy; d'Orleans-Juste, Pedro; Gobeil, Fernand; Zhu, Tang; Boisvert, Chantal; Hardy, Pierre; Jain, Kavita; Falck, J Russel; Balazy, Michael; Chemtob, Sylvain

Kermorvant-Duchemin, Elsa; Sennlaub, Florian; Sirinyan, Mirna; Brault, Sonia; Andelfinger, Gregor; Kooli, Amna; Germain, Stéphane; Ong, Huy; d'Orleans-Juste, Pedro; Gobeil, Fernand; Zhu, Tang; Boisvert, Chantal; Hardy, Pierre; Jain, Kavita; Falck, J Russel; Balazy, Michael; Chemtob, Sylvain.

Affiliation

Kermorvant-Duchemin E; Department of Pediatrics, Ophthalmology and Pharmacology, Research Center, Hôpital Ste-Justine, 3175 Côte de Ste-Catherine, Montréal, Québec, H3T1C5, Canada.

Nat Med ; 11(12): 1339-45, 2005 Dec.

Article in En | MEDLINE | ID: mdl-16311602

Subject(s)

Apoptosis/physiology; Arachidonic Acids/toxicity; Diabetic Angiopathies/metabolism; Endothelial Cells/drug effects; Gene Expression Regulation/drug effects; Neovascularization, Physiologic/drug effects; Retinal Vessels/cytology; Thrombospondin 1/metabolism; Animals; Apoptosis/drug effects; Arachidonic Acids/metabolism; Blotting, Western; Cell Survival/drug effects; Cells, Cultured; DNA Primers; In Situ Nick-End Labeling; Nitric Oxide/metabolism; Rats; Rats, Sprague-Dawley; Retinal Vessels/drug effects; Reverse Transcriptase Polymerase Chain Reaction; Sus scrofa; Tetrazolium Salts; Thiazoles

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Full text: 1 Database: MEDLINE Main subject: Retinal Vessels / Arachidonic Acids / Gene Expression Regulation / Apoptosis / Neovascularization, Physiologic / Thrombospondin 1 / Endothelial Cells / Diabetic Angiopathies Type of study: Prognostic_studies Limits: Animals Language: En Year: 2005 Type: Article

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