Nitric oxide mediates neurodegeneration and breakdown of the blood-brain barrier in tPA-dependent excitotoxic injury in mice.

Parathath, Susana R; Parathath, Saj; Tsirka, Stella E

Parathath, Susana R; Parathath, Saj; Tsirka, Stella E.

Affiliation

Parathath SR; Program in Molecular and Cellular Biology, Department of Pharmacological Sciences, University Medical Center at Stony Brook, Stony Brook, NY 11794-8651, USA.

J Cell Sci ; 119(Pt 2): 339-49, 2006 Jan 15.

Article in En | MEDLINE | ID: mdl-16410551

Subject(s)

Blood-Brain Barrier/pathology; Nitric Oxide/metabolism; Signal Transduction/physiology; Tissue Plasminogen Activator/metabolism; Animals; Blood-Brain Barrier/physiology; Excitatory Amino Acid Agonists/metabolism; Hippocampus/cytology; Hippocampus/metabolism; Hippocampus/pathology; Kainic Acid/administration & dosage; Kainic Acid/metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons/cytology; Neurons/metabolism; Neurotoxins/administration & dosage; Neurotoxins/metabolism; Nitric Oxide Donors/metabolism; Nitric Oxide Synthase/antagonists & inhibitors; Nitric Oxide Synthase/metabolism; Nitroso Compounds/metabolism; Peroxynitrous Acid/metabolism; Tissue Plasminogen Activator/genetics

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Database: MEDLINE Main subject: Blood-Brain Barrier / Signal Transduction / Tissue Plasminogen Activator / Nitric Oxide Limits: Animals Language: En Year: 2006 Type: Article

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PubMed Links

Database: MEDLINE Main subject: Blood-Brain Barrier / Signal Transduction / Tissue Plasminogen Activator / Nitric Oxide Limits: Animals Language: En Year: 2006 Type: Article