Diphenyl diselenide and 2,3-dimercaptopropanol increase the PTZ-induced chemical seizure and mortality in mice.

Brito, Verônica B; Folmer, Vanderlei; Puntel, Gustavo O; Fachinetto, Roselei; Soares, Júlio C M; Zeni, Gilson; Nogueira, Cristina W; Rocha, João B T

Brito, Verônica B; Folmer, Vanderlei; Puntel, Gustavo O; Fachinetto, Roselei; Soares, Júlio C M; Zeni, Gilson; Nogueira, Cristina W; Rocha, João B T.

Affiliation

Brito VB; Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, CAMPUS UNIVERSITRAIO-CAMOBI, 97105-900 Santa Maria, RS, Brazil.

Brain Res Bull ; 68(6): 414-8, 2006 Feb 15.

Article in En | MEDLINE | ID: mdl-16459195

Subject(s)

Benzene Derivatives/toxicity; Convulsants/toxicity; Dimercaprol/toxicity; Organoselenium Compounds/toxicity; Pentylenetetrazole/toxicity; Seizures/chemically induced; gamma-Aminobutyric Acid/metabolism; Animals; Brain/drug effects; Brain/metabolism; Brain/physiopathology; Chelating Agents/toxicity; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; GABA Antagonists/toxicity; Male; Mice; Neural Inhibition/drug effects; Neural Inhibition/physiology; Reaction Time/drug effects; Reaction Time/physiology; Receptors, GABA/drug effects; Receptors, GABA/metabolism; Seizures/metabolism; Seizures/physiopathology; Survival Rate; Time Factors

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Database: MEDLINE Main subject: Pentylenetetrazole / Seizures / Benzene Derivatives / Organoselenium Compounds / Convulsants / Dimercaprol / Gamma-Aminobutyric Acid Type of study: Prognostic_studies Limits: Animals Language: En Year: 2006 Type: Article

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