Metabolic activation of chlorpromazine by stimulated human polymorphonuclear leukocytes. Induction of covalent binding of chlorpromazine to nucleic acids and proteins.

Kelder, P P; de Mol, N J; 'T Hart, B A; Janssen, L H

Kelder, P P; de Mol, N J; 'T Hart, B A; Janssen, L H.

Affiliation

Kelder PP; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Utrecht University, The Netherlands.

Chem Biol Interact ; 79(1): 15-30, 1991.

Article in En | MEDLINE | ID: mdl-1647886

Subject(s)

Chlorpromazine/metabolism; Neutrophils/metabolism; Nucleic Acids/metabolism; Proteins/metabolism; Biotransformation; Calcimycin/pharmacology; Chromatography, High Pressure Liquid; DNA Damage; Humans; In Vitro Techniques; Luminescent Measurements; Peroxidase/metabolism; Tetradecanoylphorbol Acetate/pharmacology

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PubMed Links

Database: MEDLINE Main subject: Nucleic Acids / Proteins / Chlorpromazine / Neutrophils Limits: Humans Language: En Year: 1991 Type: Article

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PubMed Links

Database: MEDLINE Main subject: Nucleic Acids / Proteins / Chlorpromazine / Neutrophils Limits: Humans Language: En Year: 1991 Type: Article