Discovery of diphenylmethanepropionic and dihydrostilbeneacetic acids as antagonists of the integrin alphavbeta3.
Chem Biol Drug Des
; 67(2): 177-81, 2006 Feb.
Article
in En
| MEDLINE
| ID: mdl-16492166
ABSTRACT
A peptidomimetic inhibitor of the integrin alpha(v)beta(3) has been substantially modified to produce several new nonpeptidic antagonists. These inhibitors are simpler to synthesize and belong to new classes of scaffolds. Some of the compounds served as the initial lead for further optimization, which led to the discovery of potent and selective inhibitors of the integrin alpha(v)beta(3).
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Database:
MEDLINE
Main subject:
Propionates
/
Stilbenes
/
Integrin alphaVbeta3
/
Acetates
Limits:
Animals
/
Humans
Language:
En
Year:
2006
Type:
Article