The neuroactive steroid pregnenolone sulfate stimulates the release of gonadotropin-releasing hormone from GT1-7 hypothalamic neurons, through N-methyl-D-aspartate receptors.

El-Etr, Martine; Akwa, Yvette; Baulieu, Etienne-Emile; Schumacher, Michael

El-Etr, Martine; Akwa, Yvette; Baulieu, Etienne-Emile; Schumacher, Michael.

Affiliation

El-Etr M; Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 788, Université Paris 11, 94276, Le Kremlin-Bicêtre, France. eletr@kb.inserm.fr

Endocrinology ; 147(6): 2737-43, 2006 Jun.

Article in En | MEDLINE | ID: mdl-16513833

Subject(s)

Gonadotropin-Releasing Hormone/metabolism; Hypothalamus/drug effects; Pregnenolone/pharmacology; Receptors, N-Methyl-D-Aspartate/physiology; Animals; Cells, Cultured; Glutamic Acid/metabolism; Glutamic Acid/pharmacology; Glycine/metabolism; Hypothalamus/metabolism; Mice; N-Methylaspartate/pharmacology; RNA, Messenger/analysis; Receptors, AMPA/physiology; Receptors, GABA-A/physiology; Receptors, N-Methyl-D-Aspartate/genetics; Vesicular Glutamate Transport Protein 2/genetics

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Pregnenolone / Gonadotropin-Releasing Hormone / Receptors, N-Methyl-D-Aspartate / Hypothalamus Limits: Animals Language: En Year: 2006 Type: Article

Search on Google

XML

PubMed Links