The VAD chemotherapy regimen plus a G-CSF dose of 10 microg/kg is as effective and less toxic than high-dose cyclophosphamide plus a G-CSF dose of 5 microg/kg for progenitor cell mobilization: results from a monocentric study of 82 patients.

Lefrère, F; Zohar, S; Ghez, D; Delarue, R; Audat, F; Suarez, F; Hermine, O; Damaj, G; Maillard, N; Ribeil, J A; Azagury, M; Misbahi, R; Jondeau, K; Cavazzana-Calvo, M; Dal Cortivo, L; Varet, B

Lefrère, F; Zohar, S; Ghez, D; Delarue, R; Audat, F; Suarez, F; Hermine, O; Damaj, G; Maillard, N; Ribeil, J A; Azagury, M; Misbahi, R; Jondeau, K; Cavazzana-Calvo, M; Dal Cortivo, L; Varet, B.

Affiliation

Lefrère F; Service de Biothérapies, Hôpital Necker, AP-HP, Paris, France. francois.lefrere@nck.aphp.fr

Bone Marrow Transplant ; 37(8): 725-9, 2006 Apr.

Article in En | MEDLINE | ID: mdl-16518433

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Cyclophosphamide/administration & dosage; Granulocyte Colony-Stimulating Factor/administration & dosage; Hematopoietic Stem Cell Mobilization/methods; Multiple Myeloma/therapy; Antigens, CD34/biosynthesis; Cell Separation; Cyclophosphamide/metabolism; Dexamethasone/therapeutic use; Doxorubicin/therapeutic use; Female; Flow Cytometry; Granulocyte Colony-Stimulating Factor/metabolism; Granulocyte Colony-Stimulating Factor/therapeutic use; Hematopoietic Stem Cell Transplantation/methods; Humans; Male; Middle Aged; Multiple Myeloma/metabolism; Stem Cells/cytology; Time Factors; Treatment Outcome; Vincristine/therapeutic use

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Database: MEDLINE Main subject: Antineoplastic Combined Chemotherapy Protocols / Granulocyte Colony-Stimulating Factor / Hematopoietic Stem Cell Mobilization / Cyclophosphamide / Multiple Myeloma Limits: Female / Humans / Male / Middle aged Language: En Year: 2006 Type: Article

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