The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment.

Rufer, Arne C; Thoma, Ralf; Benz, Jörg; Stihle, Martine; Gsell, Bernard; De Roo, Elodie; Banner, David W; Mueller, Francis; Chomienne, Odile; Hennig, Michael

Rufer, Arne C; Thoma, Ralf; Benz, Jörg; Stihle, Martine; Gsell, Bernard; De Roo, Elodie; Banner, David W; Mueller, Francis; Chomienne, Odile; Hennig, Michael.

Affiliation

Rufer AC; F. Hoffmann-La Roche AG, Pharma Research Discovery, 4070 Basel, Switzerland.

Structure ; 14(4): 713-23, 2006 Apr.

Article in En | MEDLINE | ID: mdl-16615913

Subject(s)

Carnitine O-Palmitoyltransferase/chemistry; Crystallography, X-Ray/methods; Diabetes Mellitus/metabolism; Amino Acid Sequence; Animals; Betaine/analogs & derivatives; Betaine/chemistry; Binding Sites; Carnitine/analogs & derivatives; Carnitine/chemistry; Diabetes Mellitus/therapy; Humans; Lipid Metabolism; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mutation; Phenotype; Protein Binding; Protein Conformation; Protein Structure, Quaternary; Protein Structure, Secondary; Protein Structure, Tertiary; Proteins/chemistry; Rats; Substrate Specificity; Ultracentrifugation

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Carnitine O-Palmitoyltransferase / Crystallography, X-Ray / Diabetes Mellitus Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2006 Type: Article

Search on Google

XML

PubMed Links