Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.

Rocnik, Jennifer L; Okabe, Rachel; Yu, Jin-Chen; Lee, Benjamin H; Giese, Neill; Schenkein, David P; Gilliland, D Gary

Rocnik, Jennifer L; Okabe, Rachel; Yu, Jin-Chen; Lee, Benjamin H; Giese, Neill; Schenkein, David P; Gilliland, D Gary.

Affiliation

Rocnik JL; Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. jrocnik@rics.bwh.harvard.edu

Blood ; 108(4): 1339-45, 2006 Aug 15.

Article in En | MEDLINE | ID: mdl-16627759

Subject(s)

Cell Transformation, Neoplastic/metabolism; Leukemia, Myeloid, Acute/metabolism; Mutation; Myeloproliferative Disorders/metabolism; STAT5 Transcription Factor/metabolism; fms-Like Tyrosine Kinase 3/metabolism; Animals; Cell Transformation, Neoplastic/genetics; Cell Transformation, Neoplastic/pathology; Disease Models, Animal; Enzyme Activation/genetics; Hematopoietic Stem Cells/metabolism; Hematopoietic Stem Cells/pathology; Humans; Leukemia, Myeloid, Acute/genetics; Leukemia, Myeloid, Acute/pathology; Mice; Myeloproliferative Disorders/genetics; Myeloproliferative Disorders/pathology; Protein Structure, Tertiary/genetics; STAT5 Transcription Factor/genetics; Signal Transduction/genetics; Tyrosine/genetics; Tyrosine/metabolism; fms-Like Tyrosine Kinase 3/genetics

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Full text: 1 Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Cell Transformation, Neoplastic / Fms-Like Tyrosine Kinase 3 / STAT5 Transcription Factor / Mutation / Myeloproliferative Disorders Type of study: Prognostic_studies / Qualitative_research Limits: Animals / Humans Language: En Year: 2006 Type: Article

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