Modulators of the human CCR5 receptor. Part 3: SAR of substituted 1-[3-(4-methanesulfonylphenyl)-3-phenylpropyl]-piperidinyl phenylacetamides.

Cumming, John G; Brown, Simon J; Cooper, Anne E; Faull, Alan W; Flynn, Anthony P; Grime, Ken; Oldfield, John; Shaw, John S; Shepherd, Emma; Tucker, Howard; Whittaker, David

Cumming, John G; Brown, Simon J; Cooper, Anne E; Faull, Alan W; Flynn, Anthony P; Grime, Ken; Oldfield, John; Shaw, John S; Shepherd, Emma; Tucker, Howard; Whittaker, David.

Affiliation

Cumming JG; Respiratory and Inflammation Research Area, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK. john.cumming@astrzeneca.com

Bioorg Med Chem Lett ; 16(13): 3533-6, 2006 Jul 01.

Article in En | MEDLINE | ID: mdl-16631366

Subject(s)

Acetanilides/chemistry; Acetanilides/pharmacokinetics; CCR5 Receptor Antagonists; Piperidines/chemistry; Piperidines/pharmacology; Sulfones/chemistry; Sulfones/pharmacology; Acetanilides/chemical synthesis; Animals; Crystallography, X-Ray; Dogs; Humans; Models, Molecular; Molecular Structure; Piperidines/chemical synthesis; Rats; Stereoisomerism; Structure-Activity Relationship; Sulfones/chemical synthesis; Time Factors

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Database: MEDLINE Main subject: Piperidines / Sulfones / CCR5 Receptor Antagonists / Acetanilides Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2006 Type: Article

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