Equine laminitis induced with oligofructose.
Equine Vet J
; 38(3): 203-8, 2006 May.
Article
in En
| MEDLINE
| ID: mdl-16706272
ABSTRACT
REASONS FOR PERFORMING STUDY Experimental induction of equine laminitis with a reliable and clinically relevant model should facilitate understanding of the disease. Successful induction with oligofructose (OF) could link pasture consumption to laminitis. OBJECTIVES:
To determine whether alimentary administration of OF induces laminitis.METHODS:
Twelve horses were dosed with OF and 6 received a sham (placebo) treatment. Clinical observations were made and blood collected at 4 h intervals over a 48 h study period. Stained sections of the hoof wall lamellae, examined by light microscopy, were graded for laminitis severity.RESULTS:
All horses administered OF, but no sham-treated controls, developed clinical and histological laminitis. CONCLUSIONS AND POTENTIAL RELEVANCE Alimentary overload with OF is a valid induction model for studying the pathogenesis of laminitis. A link is therefore established between field cases of laminitis and pasture fructan content.
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Database:
MEDLINE
Main subject:
Oligosaccharides
/
Foot Diseases
/
Hoof and Claw
/
Horse Diseases
Type of study:
Etiology_studies
/
Prognostic_studies
Limits:
Animals
Language:
En
Year:
2006
Type:
Article