Plasma cell leukemia presenting with diplopia due to unilateral abducens paralysis and complex chromosomal abnormalities.
Intern Med
; 45(9): 637-40, 2006.
Article
in En
| MEDLINE
| ID: mdl-16755096
ABSTRACT
Involvement of cranial nerves is rare in plasma cell leukemia (PCL). Here, we report a case of PCL presenting with unilateral abducens paralysis. Cranial magnetic resonance imaging (MRI) disclosed a mass in the sphenoid sinus. Although the patient showed an initial response to chemotherapy, he died of disease progression 5 months later. Cytogenetic analysis showed translocation of chromosomes 11 and 14, t(11;14) (q13;q32), with additional complex abnormalities. This case implies an association between clinical manifestations and chromosomal abnormalities.
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Database:
MEDLINE
Main subject:
Paralysis
/
Leukemia, Plasma Cell
/
Chromosome Aberrations
/
Abducens Nerve Diseases
/
Diplopia
Type of study:
Diagnostic_studies
Limits:
Aged
/
Humans
/
Male
Language:
En
Year:
2006
Type:
Article