Reversal of drug resistance in a human colon cancer xenograft expressing MDR1 complementary DNA by in vivo administration of MRK-16 monoclonal antibody.

Pearson, J W; Fogler, W E; Volker, K; Usui, N; Goldenberg, S K; Gruys, E; Riggs, C W; Komschlies, K; Wiltrout, R H; Tsuruo, T

Pearson, J W; Fogler, W E; Volker, K; Usui, N; Goldenberg, S K; Gruys, E; Riggs, C W; Komschlies, K; Wiltrout, R H; Tsuruo, T.

Affiliation

Pearson JW; Laboratory of Experimental Immunology, National Cancer Institute, NCI-Frederick Cancer Research and Development Center (NCI-FCRDC), Md. 21702-1201.

J Natl Cancer Inst ; 83(19): 1386-91, 1991 Oct 02.

Article in En | MEDLINE | ID: mdl-1681110

Subject(s)

Antibodies, Monoclonal/administration & dosage; Colonic Neoplasms/drug therapy; DNA, Neoplasm/genetics; ATP Binding Cassette Transporter, Subfamily B, Member 1; Animals; Antibodies, Monoclonal/immunology; Cell Survival/drug effects; Colonic Neoplasms/genetics; Colonic Neoplasms/pathology; Drug Resistance/genetics; Female; Humans; Male; Membrane Glycoproteins/genetics; Membrane Glycoproteins/immunology; Mice; Mice, Nude; Neoplasm Transplantation; Retroviridae Infections/pathology; Tumor Cells, Cultured; Vincristine/pharmacology; Vincristine/toxicity

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Database: MEDLINE Main subject: DNA, Neoplasm / Colonic Neoplasms / Antibodies, Monoclonal Limits: Animals / Female / Humans / Male Language: En Year: 1991 Type: Article

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PubMed Links

Database: MEDLINE Main subject: DNA, Neoplasm / Colonic Neoplasms / Antibodies, Monoclonal Limits: Animals / Female / Humans / Male Language: En Year: 1991 Type: Article