Oral misoprostol vs. intravenous oxytocin in reducing blood loss after emergency cesarean delivery.
Int J Gynaecol Obstet
; 95(1): 2-7, 2006 Oct.
Article
in En
| MEDLINE
| ID: mdl-16934269
ABSTRACT
OBJECTIVE:
To compare the effectiveness of oral misoprostol and intravenous oxytocin in reducing blood loss in women undergoing indicated or elective cesarean delivery (CD) under spinal anesthesia.METHODS:
In this prospective, double-blind pilot study, 56 parturients who received 5 IU of intravenous oxytocin after cord clamping were randomized to further receive either misoprostol orally and a placebo infusion intravenously or placebo orally and an oxytocin infusion intravenously.RESULTS:
After adjustment was made for the sonographically estimated amniotic fluid volume, there was no statistical difference in blood loss between the 2 groups (mean+/-S.D., 1083+/-920 mL in the oxytocin group vs. 970+/-560 mL in the misoprostol group; P=.59).CONCLUSION:
Oxytocin followed by oral misoprostol is as effective as an oxytocin injection followed by an oxytocin infusion in reducing postoperative blood loss after CD, and the protocol may be a safe, valuable, and cost-effective alternative to oxytocin alone. Visual estimation of intraoperative blood loss undervalues the effective value of misoprostol use by 30%.
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Database:
MEDLINE
Main subject:
Oxytocics
/
Oxytocin
/
Cesarean Section
/
Misoprostol
/
Postpartum Hemorrhage
/
Hemostasis, Surgical
Type of study:
Clinical_trials
/
Observational_studies
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
En
Year:
2006
Type:
Article