IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression.

Rajasingh, Johnson; Bord, Evelyn; Luedemann, Corinne; Asai, Jun; Hamada, Hiromichi; Thorne, Tina; Qin, Gangjian; Goukassian, David; Zhu, Yan; Losordo, Douglas W; Kishore, Raj

Rajasingh, Johnson; Bord, Evelyn; Luedemann, Corinne; Asai, Jun; Hamada, Hiromichi; Thorne, Tina; Qin, Gangjian; Goukassian, David; Zhu, Yan; Losordo, Douglas W; Kishore, Raj.

Affiliation

Rajasingh J; Division of Cardiovascular Research, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA.

FASEB J ; 20(12): 2112-4, 2006 Oct.

Article in En | MEDLINE | ID: mdl-16935932

Subject(s)

Interleukin-10/pharmacology; RNA-Binding Proteins/antagonists & inhibitors; Tumor Necrosis Factor-alpha/genetics; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors; Animals; Antigens, Surface/genetics; Carotid Artery Injuries; Cell Line; Cytokines/analysis; Down-Regulation/drug effects; Down-Regulation/genetics; ELAV Proteins; ELAV-Like Protein 1; Enzyme Activation/drug effects; Humans; Interleukin-10/therapeutic use; Mice; Monocytes; RNA Processing, Post-Transcriptional; RNA Stability/drug effects; RNA, Messenger/drug effects; RNA-Binding Proteins/genetics; Transfection

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PubMed Links

Database: MEDLINE Main subject: Tumor Necrosis Factor-alpha / RNA-Binding Proteins / Interleukin-10 / P38 Mitogen-Activated Protein Kinases Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2006 Type: Article

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