Angiogenesis Inhibitors/physiology; Capillaries/growth & development; Endothelium, Vascular/growth & development; Pericytes/metabolism; Tissue Inhibitor of Metalloproteinase-2/physiology; Tissue Inhibitor of Metalloproteinase-3/physiology; ADAM Proteins/genetics; ADAM Proteins/metabolism; Angiogenesis Inhibitors/genetics; Animals; Capillaries/cytology; Capillaries/metabolism; Cattle; Collagen; Embryo, Mammalian/blood supply; Embryo, Mammalian/metabolism; Endothelium, Vascular/cytology; Endothelium, Vascular/metabolism; Gene Expression Regulation; Humans; Matrix Metalloproteinase 1/metabolism; Matrix Metalloproteinase 10/metabolism; Matrix Metalloproteinases, Membrane-Associated/genetics; Matrix Metalloproteinases, Membrane-Associated/metabolism; Membrane Proteins/genetics; Membrane Proteins/metabolism; Mice; Models, Cardiovascular; Mutagenesis; RNA Interference; Tissue Inhibitor of Metalloproteinase-2/antagonists & inhibitors; Tissue Inhibitor of Metalloproteinase-2/genetics; Tissue Inhibitor of Metalloproteinase-3/antagonists & inhibitors; Tissue Inhibitor of Metalloproteinase-3/genetics