Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK.

Peregrin, Sandra; Jurado-Pueyo, Maria; Campos, Pedro M; Sanz-Moreno, Victoria; Ruiz-Gomez, Ana; Crespo, Piero; Mayor, Federico; Murga, Cristina

Peregrin, Sandra; Jurado-Pueyo, Maria; Campos, Pedro M; Sanz-Moreno, Victoria; Ruiz-Gomez, Ana; Crespo, Piero; Mayor, Federico; Murga, Cristina.

Affiliation

Peregrin S; Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid, 28049 Madrid, Spain.

Curr Biol ; 16(20): 2042-7, 2006 Oct 24.

Article in En | MEDLINE | ID: mdl-17055984

Subject(s)

Down-Regulation; beta-Adrenergic Receptor Kinases/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism; Animals; Blotting, Western; Cell Line; DNA Primers; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation/physiology; G-Protein-Coupled Receptor Kinase 2; Humans; Immunoprecipitation; Macrophages/metabolism; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mutagenesis, Site-Directed; Phosphorylation; Tumor Necrosis Factor-alpha/metabolism; p38 Mitogen-Activated Protein Kinases/genetics

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Database: MEDLINE Main subject: Down-Regulation / P38 Mitogen-Activated Protein Kinases / Beta-Adrenergic Receptor Kinases Limits: Animals / Humans Language: En Year: 2006 Type: Article

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