TGFbeta1 induces vasculogenesis and inhibits angiogenic sprouting in an embryonic stem cell differentiation model: respective contribution of ALK1 and ALK5.

Mallet, Christine; Vittet, Daniel; Feige, Jean-Jacques; Bailly, Sabine

Mallet, Christine; Vittet, Daniel; Feige, Jean-Jacques; Bailly, Sabine.

Affiliation

Mallet C; Institut National de la Santé et de la Recherche Médicale (INSERM) EMI 01-05, Département Réponse et Dynamique Cellulaires (DRDC), Commissariat à l'Energie Atomique (CEA)-Grenoble, France.

Stem Cells ; 24(11): 2420-7, 2006 Nov.

Article in En | MEDLINE | ID: mdl-17071858

Subject(s)

Activin Receptors, Type I/metabolism; Blood Vessels/metabolism; Cell Differentiation; Embryonic Stem Cells/metabolism; Neovascularization, Physiologic; Receptors, Transforming Growth Factor beta/metabolism; Transforming Growth Factor beta1/metabolism; Activin Receptors, Type I/genetics; Activin Receptors, Type II; Animals; Blood Vessels/drug effects; Blood Vessels/embryology; Cell Differentiation/drug effects; Cells, Cultured; Embryonic Stem Cells/drug effects; Endothelial Cells/drug effects; Endothelial Cells/metabolism; Flow Cytometry; Gene Expression Regulation, Developmental/drug effects; Immunohistochemistry; Kinetics; Mice; Neovascularization, Physiologic/drug effects; Protein Serine-Threonine Kinases; RNA, Messenger/metabolism; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta/genetics; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta1/pharmacology; Vascular Endothelial Growth Factor A/metabolism

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Database: MEDLINE Main subject: Blood Vessels / Cell Differentiation / Receptors, Transforming Growth Factor beta / Neovascularization, Physiologic / Activin Receptors, Type I / Embryonic Stem Cells / Transforming Growth Factor beta1 Type of study: Prognostic_studies Limits: Animals Language: En Year: 2006 Type: Article

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