1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile.

Fancelli, Daniele; Moll, Jürgen; Varasi, Mario; Bravo, Rodrigo; Artico, Roberta; Berta, Daniela; Bindi, Simona; Cameron, Alexander; Candiani, Ilaria; Cappella, Paolo; Carpinelli, Patrizia; Croci, Walter; Forte, Barbara; Giorgini, Maria Laura; Klapwijk, Jan; Marsiglio, Aurelio; Pesenti, Enrico; Rocchetti, Maurizio; Roletto, Fulvia; Severino, Dino; Soncini, Chiara; Storici, Paola; Tonani, Roberto; Zugnoni, Paola; Vianello, Paola

Fancelli, Daniele; Moll, Jürgen; Varasi, Mario; Bravo, Rodrigo; Artico, Roberta; Berta, Daniela; Bindi, Simona; Cameron, Alexander; Candiani, Ilaria; Cappella, Paolo; Carpinelli, Patrizia; Croci, Walter; Forte, Barbara; Giorgini, Maria Laura; Klapwijk, Jan; Marsiglio, Aurelio; Pesenti, Enrico; Rocchetti, Maurizio; Roletto, Fulvia; Severino, Dino; Soncini, Chiara; Storici, Paola; Tonani, Roberto; Zugnoni, Paola; Vianello, Paola.

Affiliation

Fancelli D; Nerviano Medical Sciences S.r.l. viale Pasteur 10, 20014 Nerviano, Milan, Italy.

J Med Chem ; 49(24): 7247-51, 2006 Nov 30.

Article in En | MEDLINE | ID: mdl-17125279

Subject(s)

Antineoplastic Agents/chemical synthesis; Protein Serine-Threonine Kinases/antagonists & inhibitors; Pyrazoles/chemical synthesis; Pyrroles/chemical synthesis; Animals; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Aurora Kinases; Cell Line, Tumor; Drug Screening Assays, Antitumor; Male; Mice; Models, Molecular; Pyrazoles/pharmacokinetics; Pyrazoles/pharmacology; Pyrroles/pharmacokinetics; Pyrroles/pharmacology; Solubility; Structure-Activity Relationship

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Database: MEDLINE Main subject: Pyrazoles / Pyrroles / Protein Serine-Threonine Kinases / Antineoplastic Agents Type of study: Diagnostic_studies Limits: Animals Language: En Year: 2006 Type: Article

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