Dequalinium induces cell death in human leukemia cells by early mitochondrial alterations which enhance ROS production.
Leuk Res
; 31(7): 969-78, 2007 Jul.
Article
in En
| MEDLINE
| ID: mdl-17250890
ABSTRACT
Dequalinium (DQA) has been proposed as a selective antitumoral agent due to its preferential accumulation in mitochondria of cancer cells. Our aim was a better understanding of DQA cytotoxicity. DQA-induced NB4 and K562 cell alterations are initiated within the first 30 min of treatment at a high DQA concentration with a mitochondrial membrane depolarization. Cytochrome c release to cytoplasm, superoxide anion overproduction and ATP depletion in NB4 cells induce, 16 h later, apoptosis by a typical caspase-9/caspase-3-dependent intrinsic pathway. K562 cells were more resistant to the DQA effect than NB4 cells, remaining viable for longer time periods.
Search on Google
Database:
MEDLINE
Main subject:
Leukemia
/
Reactive Oxygen Species
/
Apoptosis
/
Superoxides
/
Dequalinium
/
Mitochondria
/
Antineoplastic Agents
Limits:
Humans
Language:
En
Year:
2007
Type:
Article