Differential regulation of the serotonin transporter gene by lithium is mediated by transcription factors, CCCTC binding protein and Y-box binding protein 1, through the polymorphic intron 2 variable number tandem repeat.

Roberts, Julian; Scott, Alison C; Howard, Mark R; Breen, Gerome; Bubb, Vivien J; Klenova, Elena; Quinn, John P

Roberts, Julian; Scott, Alison C; Howard, Mark R; Breen, Gerome; Bubb, Vivien J; Klenova, Elena; Quinn, John P.

Affiliation

Roberts J; Physiology Laboratory, School of Biomedical Science, University of Liverpool, Liverpool L69 3BX, United Kingdom.

J Neurosci ; 27(11): 2793-801, 2007 Mar 14.

Article in En | MEDLINE | ID: mdl-17360901

Subject(s)

DNA-Binding Proteins/genetics; Lithium/pharmacology; Minisatellite Repeats/genetics; Polymorphism, Genetic/genetics; Repressor Proteins/genetics; Serotonin Plasma Membrane Transport Proteins/genetics; Y-Box-Binding Protein 1/genetics; CCCTC-Binding Factor; Cell Line; DNA-Binding Proteins/biosynthesis; Humans; Introns/drug effects; Introns/genetics; Minisatellite Repeats/drug effects; Protein Binding/drug effects; Protein Binding/physiology; Repressor Proteins/biosynthesis; Serotonin Plasma Membrane Transport Proteins/biosynthesis; Transcription Factors/biosynthesis; Transcription Factors/genetics; Y-Box-Binding Protein 1/biosynthesis

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Full text: 1 Database: MEDLINE Main subject: Polymorphism, Genetic / Repressor Proteins / Minisatellite Repeats / DNA-Binding Proteins / Serotonin Plasma Membrane Transport Proteins / Y-Box-Binding Protein 1 / Lithium Type of study: Prognostic_studies Limits: Humans Language: En Year: 2007 Type: Article

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