Detection of a neonatal human rotavirus strain with VP4 and NSP4 genes of porcine origin.
J Med Microbiol
; 56(Pt 4): 524-532, 2007 Apr.
Article
in En
| MEDLINE
| ID: mdl-17374895
ABSTRACT
A human rotavirus strain (NB-150) was detected in stool samples from a neonate hospitalized for mild/moderate community-acquired diarrhoea. This baby lived in the outskirts of Belém, Brazil, under poor sanitation conditions. The NB-150 strain displayed a typical long electrophoretic pattern with 11 gene segments. It had two VP7 alleles, G1 and G4, and belonged to VP6 subgroup II. A close relatedness with human rotaviruses was shown for VP7 alleles G1 (96.9-100 % similarity at the amino acid level) and G4 (97.1-100 % similarity at the amino acid level). As for VP6, 95.1-97.5 % similarity at the amino acid level was noted. VP8* and NSP4 genes showed a close relatedness with those of porcine rotavirus strains, as follows VP8* (95.0 % similarity at the amino acid level) and NSP4 (93.7-96.0 % similarity at the amino acid level). This is believed to be the first report in Brazil of a rotavirus infection involving a strain with G1 and G4 alleles, with VP8* and NSP4 genes of porcine origin. These findings strongly suggest the occurrence of interspecies transmission.
Full text:
1
Database:
MEDLINE
Main subject:
Rotavirus Infections
/
Toxins, Biological
/
Glycoproteins
/
Viral Nonstructural Proteins
/
Rotavirus
/
Capsid Proteins
Type of study:
Diagnostic_studies
Limits:
Animals
/
Humans
/
Newborn
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Year:
2007
Type:
Article