Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1.

Rodríguez-Martínez, J M; Velasco, C; García, I; Cano, M E; Martínez-Martínez, L; Pascual, A

Rodríguez-Martínez, J M; Velasco, C; García, I; Cano, M E; Martínez-Martínez, L; Pascual, A.

Affiliation

Rodríguez-Martínez JM; Department of Microbiology, University of Seville, Sanchez Pizjuan s/n, Seville 41009, Spain. jmrodriguez@us.es

Antimicrob Agents Chemother ; 51(6): 2236-9, 2007 Jun.

Article in En | MEDLINE | ID: mdl-17404007

ABSTRACT

ABSTRACT

The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant prevention concentration parameter. The expression of qnrA1 considerably increased the mutant prevention concentration compared to strains without this gene. In the presence of qnrA1, mutations in gyrA and parC genes were easily selected to produce high levels of quinolone resistance.

Subject(s)

Anti-Infective Agents/pharmacology; Bacterial Proteins/metabolism; Drug Resistance, Bacterial/genetics; Enterobacteriaceae/drug effects; Fluoroquinolones/pharmacology; Mutation; Plasmids; Bacterial Proteins/genetics; Colony Count, Microbial; Dose-Response Relationship, Drug; Enterobacteriaceae/genetics; Enterobacteriaceae/growth & development; Escherichia coli Proteins/genetics; Humans; Microbial Sensitivity Tests

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Full text: 1 Database: MEDLINE Main subject: Plasmids / Bacterial Proteins / Fluoroquinolones / Drug Resistance, Bacterial / Enterobacteriaceae / Anti-Infective Agents / Mutation Limits: Humans Language: En Year: 2007 Type: Article

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