Complex chromosome 8;21 translocation with associated hyperdiploidy in acute myeloid leukemia (FAB-M2).
Pediatr Blood Cancer
; 50(3): 651-4, 2008 Mar.
Article
in En
| MEDLINE
| ID: mdl-17405156
ABSTRACT
We present a case of acute myeloblastic leukemia (AML-M2) with a complex t(8;21) translocation and additional acquired chromosomes yielding a hyperdiploid karyotype. AML1/ETO transcript was observed by reverse transcription-polymerase chain reaction. Fluorescence in situ hybridization (FISH), spectral karyotyping (SKY), and comparative genomic hybridization (CGH) were performed to further identify the chromosomes observed by G banding. The patient was treated according to our current protocol for AML. He remains in complete remission +11 months from diagnosis. Further follow-up of this patient and the analysis of a larger number of children are needed to define whether the gains of the specific extra chromosomes modify the good prognosis that t(8;21) confers to this subgroup of AML.
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Database:
MEDLINE
Main subject:
Translocation, Genetic
/
Chromosomes, Human, Pair 8
/
Chromosomes, Human, Pair 21
/
Leukemia, Myeloid, Acute
/
Oncogene Proteins, Fusion
/
Core Binding Factor Alpha 2 Subunit
/
Aneuploidy
Type of study:
Guideline
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Child
/
Humans
/
Male
Language:
En
Year:
2008
Type:
Article