The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing.

Papin, S; Cuenin, S; Agostini, L; Martinon, F; Werner, S; Beer, H-D; Grütter, C; Grütter, M; Tschopp, J

Papin, S; Cuenin, S; Agostini, L; Martinon, F; Werner, S; Beer, H-D; Grütter, C; Grütter, M; Tschopp, J.

Affiliation

Papin S; Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland.

Cell Death Differ ; 14(8): 1457-66, 2007 Aug.

Article in En | MEDLINE | ID: mdl-17431422

Subject(s)

Cytoskeletal Proteins/chemistry; Cytoskeletal Proteins/metabolism; Familial Mediterranean Fever/genetics; Familial Mediterranean Fever/metabolism; Interleukin-1/metabolism; Protein Precursors/metabolism; Autoimmunity; Base Sequence; Carrier Proteins/metabolism; Caspase 1/metabolism; Caspase Inhibitors; Cell Line; Cytoskeletal Proteins/genetics; DNA/genetics; Familial Mediterranean Fever/immunology; Humans; In Vitro Techniques; Models, Biological; Mutation; NLR Family, Pyrin Domain-Containing 3 Protein; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Pyrin; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Transfection

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Database: MEDLINE Main subject: Familial Mediterranean Fever / Protein Precursors / Interleukin-1 / Cytoskeletal Proteins Type of study: Prognostic_studies Limits: Humans Language: En Year: 2007 Type: Article

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