[Discrimination of heterozygote currency of ataxia-telangiectasia by indirect immunofluorescent analysis].

Spivak, I M; Smirnova, N V; Pleskach, N M; Ledashcheva, T A; Mikhel'son, V M

Spivak, I M; Smirnova, N V; Pleskach, N M; Ledashcheva, T A; Mikhel'son, V M.

Tsitologiia ; 49(1): 55-61, 2007.

Article in Ru | MEDLINE | ID: mdl-17432608

ABSTRACT

ABSTRACT

The qualitative differences in P53 protein stabilization after ionizing irradiation in different doses were found in cells of members of ataxia-telangiectasia (AT) family--proband AT6SP, her sister AT(S)6SP and father AT(F)6SP. The method of indirect immunofluorescence with confocal microscopy was used.

Subject(s)

Ataxia Telangiectasia/genetics; Heterozygote; Adolescent; Adult; Ataxia Telangiectasia/metabolism; Cells, Cultured; Child; Dose-Response Relationship, Radiation; Female; Fluorescent Antibody Technique; Gamma Rays; Humans; Male; Middle Aged; Tumor Suppressor Protein p53/analysis; Tumor Suppressor Protein p53/metabolism; Tumor Suppressor Protein p53/radiation effects

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Ataxia Telangiectasia / Heterozygote Type of study: Prognostic_studies / Qualitative_research Limits: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Language: Ru Year: 2007 Type: Article

Search on Google

XML

PubMed Links