Evidence from gene knockout studies implicates Asc-1 as the primary transporter mediating d-serine reuptake in the mouse CNS.

Rutter, A Richard; Fradley, Rosa L; Garrett, Elizabeth M; Chapman, Kerry L; Lawrence, Jason M; Rosahl, Thomas W; Patel, Smita

Rutter, A Richard; Fradley, Rosa L; Garrett, Elizabeth M; Chapman, Kerry L; Lawrence, Jason M; Rosahl, Thomas W; Patel, Smita.

Affiliation

Rutter AR; Department of Molecular and Cellular Neuroscience, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Harlow, Essex, UK. richard.a.rutter@gsk.com

Eur J Neurosci ; 25(6): 1757-66, 2007 Mar.

Article in En | MEDLINE | ID: mdl-17432963

Subject(s)

Amino Acid Transport System y+/deficiency; Amino Acid Transport System y+/physiology; Central Nervous System/metabolism; Serine/metabolism; Amino Acid Transport Systems/deficiency; Amino Acid Transport Systems/metabolism; Animals; Biological Transport/drug effects; Biological Transport/genetics; Cells, Cultured; Central Nervous System/cytology; Dose-Response Relationship, Drug; Embryo, Mammalian; Mice; Mice, Inbred C57BL; Mice, Knockout; Serine/pharmacokinetics; Sodium/metabolism; Synaptosomes/metabolism; Synaptosomes/ultrastructure

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Serine / Central Nervous System / Amino Acid Transport System y/ Limits: Animals Language: En Year: 2007 Type: Article

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Serine / Central Nervous System / Amino Acid Transport System y/ Limits: Animals Language: En Year: 2007 Type: Article