Development of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as orally active human chymase inhibitors.
Bioorg Med Chem Lett
; 17(12): 3435-9, 2007 Jun 15.
Article
in En
| MEDLINE
| ID: mdl-17434735
ABSTRACT
A novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones was designed, synthesized, and evaluated as human chymase inhibitors. From this series, we identified several compounds which were effective, via oral administration, in a mouse model of chronic dermatitis.
Search on Google
Database:
MEDLINE
Main subject:
Azepines
/
Benzyl Compounds
/
Serine Proteinase Inhibitors
/
Dermatitis
/
Chymases
Limits:
Animals
/
Humans
Language:
En
Year:
2007
Type:
Article