EGFR inhibition in glioblastoma cells induces G2/M arrest and is independent of p53.

Kapoor, Gurpreet S; Christie, Antoire; O'Rourke, Donald M

Kapoor, Gurpreet S; Christie, Antoire; O'Rourke, Donald M.

Affiliation

Kapoor GS; Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

Cancer Biol Ther ; 6(4): 571-9, 2007 Apr.

Article in En | MEDLINE | ID: mdl-17457042

Subject(s)

Cell Proliferation; Central Nervous System Neoplasms/metabolism; ErbB Receptors/antagonists & inhibitors; Glioblastoma/metabolism; Tumor Suppressor Protein p53/metabolism; Animals; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Transformation, Neoplastic/genetics; Cell Transformation, Neoplastic/metabolism; ErbB Receptors/metabolism; G2 Phase; Humans; Mice; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Mutation; Proto-Oncogene Proteins c-akt/metabolism; Receptor, ErbB-2/genetics; Receptor, ErbB-2/metabolism; Tumor Suppressor Protein p53/genetics

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Database: MEDLINE Main subject: Tumor Suppressor Protein p53 / Central Nervous System Neoplasms / Glioblastoma / Cell Proliferation / ErbB Receptors Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2007 Type: Article

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