Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites.

Plenge, Per; Gether, Ulrik; Rasmussen, Søren G

Plenge, Per; Gether, Ulrik; Rasmussen, Søren G.

Affiliation

Plenge P; Laboratory of Neuropsychiatry, Department of Neuroscience and Pharmacology, Rigshospitalet-6102, Blegdamsvej, DK-2100 Copenhagen, Denmark. plenge@rh.dk

Eur J Pharmacol ; 567(1-2): 1-9, 2007 Jul 12.

Article in En | MEDLINE | ID: mdl-17499240

Subject(s)

Antidepressive Agents/pharmacology; Citalopram/pharmacology; Serotonin Plasma Membrane Transport Proteins/metabolism; Allosteric Regulation; Animals; Antidepressive Agents/chemistry; Binding Sites; COS Cells; Chlorocebus aethiops; Citalopram/chemistry; Humans; Mutagenesis, Site-Directed; Paroxetine/pharmacology; Radioligand Assay; Serotonin Plasma Membrane Transport Proteins/genetics; Stereoisomerism

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Citalopram / Serotonin Plasma Membrane Transport Proteins / Antidepressive Agents Limits: Animals / Humans Language: En Year: 2007 Type: Article

Search on Google

XML

PubMed Links