The effects of N-terminal part modification of arginine vasopressin analogues with 2-aminoindane-2-carboxylic acid: a highly potent V2 agonist.

Kowalczyk, Wioleta; Sobolewski, Dariusz; Prahl, Adam; Derdowska, Izabela; Borovicková, Lenka; Slaninová, Jirina; Lammek, Bernard

Kowalczyk, Wioleta; Sobolewski, Dariusz; Prahl, Adam; Derdowska, Izabela; Borovicková, Lenka; Slaninová, Jirina; Lammek, Bernard.

Affiliation

Kowalczyk W; Faculty of Chemistry, University of Gdansk, Sobieskiego 18, 80-952 Gdansk, Poland. wiola@chem.univ-gda.pl

J Med Chem ; 50(12): 2926-9, 2007 Jun 14.

Article in En | MEDLINE | ID: mdl-17500550

Subject(s)

Antidiuretic Agents/chemical synthesis; Arginine Vasopressin/analogs & derivatives; Arginine Vasopressin/chemical synthesis; Carboxylic Acids/chemical synthesis; Receptors, Vasopressin/agonists; Animals; Antidiuretic Agents/pharmacology; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin/pharmacology; Blood Pressure/drug effects; Carboxylic Acids/pharmacology; Female; In Vitro Techniques; Protein Conformation; Rats; Rats, Wistar; Structure-Activity Relationship; Uterine Contraction/drug effects

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Database: MEDLINE Main subject: Arginine Vasopressin / Carboxylic Acids / Receptors, Vasopressin / Antidiuretic Agents Limits: Animals Language: En Year: 2007 Type: Article

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PubMed Links

Database: MEDLINE Main subject: Arginine Vasopressin / Carboxylic Acids / Receptors, Vasopressin / Antidiuretic Agents Limits: Animals Language: En Year: 2007 Type: Article