Synthesis, characterization, and metal coordinating ability of multifunctional carbohydrate-containing compounds for Alzheimer's therapy.

Storr, Tim; Merkel, Michael; Song-Zhao, George X; Scott, Lauren E; Green, David E; Bowen, Meryn L; Thompson, Katherine H; Patrick, Brian O; Schugar, Harvey J; Orvig, Chris

Storr, Tim; Merkel, Michael; Song-Zhao, George X; Scott, Lauren E; Green, David E; Bowen, Meryn L; Thompson, Katherine H; Patrick, Brian O; Schugar, Harvey J; Orvig, Chris.

Affiliation

Storr T; Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia, V6T 1Z1, Canada.

J Am Chem Soc ; 129(23): 7453-63, 2007 Jun 13.

Article in En | MEDLINE | ID: mdl-17511455

Subject(s)

Alzheimer Disease/drug therapy; Antioxidants/chemistry; Carbohydrates/chemistry; Chelating Agents/chemistry; Drug Design; Glucosides/chemical synthesis; Metals, Heavy/chemistry; Antioxidants/chemical synthesis; Antioxidants/therapeutic use; Chelating Agents/chemical synthesis; Chelating Agents/therapeutic use; Copper/chemistry; Crystallography, X-Ray; Glucosides/chemistry; Iron/chemistry; Ligands; Metals, Heavy/metabolism; Molecular Structure; Potentiometry; Zinc/chemistry

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PubMed Links

Database: MEDLINE Main subject: Carbohydrates / Drug Design / Chelating Agents / Metals, Heavy / Alzheimer Disease / Glucosides / Antioxidants Language: En Year: 2007 Type: Article

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