Alternative BCR/ABL splice variants in Philadelphia chromosome-positive leukemias result in novel tumor-specific fusion proteins that may represent potential targets for immunotherapy approaches.

Volpe, Gisella; Cignetti, Alessandro; Panuzzo, Cristina; Kuka, Mirela; Vitaggio, Katiuscia; Brancaccio, Mara; Perrone, Giuseppe; Rinaldi, Monica; Prato, Giuseppina; Fava, Milena; Geuna, Massimo; Pautasso, Marisa; Casnici, Claudia; Signori, Emanuela; Tonon, Giancarlo; Tarone, Guido; Marelli, Ornella; Fazio, Vito M; Saglio, Giuseppe

Volpe, Gisella; Cignetti, Alessandro; Panuzzo, Cristina; Kuka, Mirela; Vitaggio, Katiuscia; Brancaccio, Mara; Perrone, Giuseppe; Rinaldi, Monica; Prato, Giuseppina; Fava, Milena; Geuna, Massimo; Pautasso, Marisa; Casnici, Claudia; Signori, Emanuela; Tonon, Giancarlo; Tarone, Guido; Marelli, Ornella; Fazio, Vito M; Saglio, Giuseppe.

Affiliation

Volpe G; Department of Clinical, University of Turin, Turin, Italy. gisella.volpe@unito.it

Cancer Res ; 67(11): 5300-7, 2007 Jun 01.

Article in En | MEDLINE | ID: mdl-17545610

Subject(s)

Fusion Proteins, bcr-abl/immunology; Immunotherapy/methods; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/immunology; Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunology; Antigens, Neoplasm/immunology; CD8-Positive T-Lymphocytes/immunology; Epitopes, T-Lymphocyte/immunology; Exons; Fusion Proteins, bcr-abl/genetics; HLA-A2 Antigen/immunology; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/therapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy; Protein Isoforms; RNA, Messenger/genetics; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes, Cytotoxic/immunology

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Database: MEDLINE Main subject: Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Fusion Proteins, bcr-abl / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Immunotherapy Limits: Humans Language: En Year: 2007 Type: Article

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