Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates.

Dalrymple, Annette; Wild, Edward J; Joubert, Richard; Sathasivam, Kirupa; Björkqvist, Maria; Petersén, Asa; Jackson, Graham S; Isaacs, Jeremy D; Kristiansen, Mark; Bates, Gillian P; Leavitt, Blair R; Keir, Geoff; Ward, Malcolm; Tabrizi, Sarah J

Dalrymple, Annette; Wild, Edward J; Joubert, Richard; Sathasivam, Kirupa; Björkqvist, Maria; Petersén, Asa; Jackson, Graham S; Isaacs, Jeremy D; Kristiansen, Mark; Bates, Gillian P; Leavitt, Blair R; Keir, Geoff; Ward, Malcolm; Tabrizi, Sarah J.

Affiliation

Dalrymple A; Proteome Sciences PLC, Cobham, Surrey, United Kingdom.

J Proteome Res ; 6(7): 2833-40, 2007 Jul.

Article in En | MEDLINE | ID: mdl-17552550

ABSTRACT

ABSTRACT

Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers.

Subject(s)

Blood Proteins/analysis; Central Nervous System/metabolism; Encephalitis/blood; Huntington Disease/blood; Proteomics; Animals; Biomarkers/blood; Blotting, Western; Electrophoresis, Gel, Two-Dimensional; Encephalitis/immunology; Enzyme-Linked Immunosorbent Assay; Humans; Huntington Disease/immunology; Interleukin-6/blood; Mice; Protein Array Analysis

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Database: MEDLINE Main subject: Blood Proteins / Central Nervous System / Huntington Disease / Proteomics / Encephalitis Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2007 Type: Article

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