Inactivation of CYP2D6 by methylenedioxymethamphetamine in different recombinant expression systems.

Van, Linh M; Hargreaves, Judith A; Lennard, Martin S; Tucker, Geoffrey T; Rostami-Hodjegan, Amin

Van, Linh M; Hargreaves, Judith A; Lennard, Martin S; Tucker, Geoffrey T; Rostami-Hodjegan, Amin.

Affiliation

Van LM; University of Sheffield, Academic Unit of Clinical Pharmacology, University of Sheffield, Sheffield S10 2JF, UK.

Eur J Pharm Sci ; 32(1): 8-16, 2007 Sep.

Article in En | MEDLINE | ID: mdl-17574396

Subject(s)

Cytochrome P-450 CYP2D6 Inhibitors; Enzyme Inhibitors/pharmacology; N-Methyl-3,4-methylenedioxyamphetamine/pharmacology; Recombinant Proteins/antagonists & inhibitors; Cytochrome P-450 CYP2D6/genetics; Cytochrome P-450 CYP2D6/metabolism; Dextromethorphan/pharmacology; Dextrorphan/pharmacology; Humans; Kinetics; Microsomes/drug effects; Microsomes/enzymology; Microsomes/metabolism; Recombinant Proteins/metabolism; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism

Search on Google

XML

PubMed Links

Database: MEDLINE Main subject: Recombinant Proteins / N-Methyl-3,4-methylenedioxyamphetamine / Enzyme Inhibitors / Cytochrome P-450 CYP2D6 Inhibitors Limits: Humans Language: En Year: 2007 Type: Article

Search on Google

XML

PubMed Links