Prophylactic treatment with levetiracetam after status epilepticus: lack of effect on epileptogenesis, neuronal damage, and behavioral alterations in rats.

Brandt, Claudia; Glien, Maike; Gastens, Alexandra M; Fedrowitz, Maren; Bethmann, Kerstin; Volk, Holger A; Potschka, Heidrun; Löscher, Wolfgang

Brandt, Claudia; Glien, Maike; Gastens, Alexandra M; Fedrowitz, Maren; Bethmann, Kerstin; Volk, Holger A; Potschka, Heidrun; Löscher, Wolfgang.

Affiliation

Brandt C; Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Bünteweg 17, D-30559 Hannover, Germany.

Neuropharmacology ; 53(2): 207-21, 2007 Aug.

Article in En | MEDLINE | ID: mdl-17585956

Subject(s)

Anticonvulsants/administration & dosage; Behavior, Animal/drug effects; Brain Damage, Chronic/prevention & control; Piracetam/analogs & derivatives; Status Epilepticus/drug therapy; Amygdala/physiology; Amygdala/radiation effects; Analysis of Variance; Animals; Brain Damage, Chronic/pathology; Diazepam/administration & dosage; Disease Models, Animal; Drug Administration Schedule; Electric Stimulation/adverse effects; Exploratory Behavior/drug effects; Exploratory Behavior/physiology; Female; Hippocampus/drug effects; Hippocampus/pathology; Hyperkinesis/drug therapy; Hyperkinesis/etiology; Levetiracetam; Maze Learning/drug effects; Maze Learning/physiology; Piracetam/administration & dosage; Rats; Rats, Sprague-Dawley; Status Epilepticus/complications; Status Epilepticus/etiology; Status Epilepticus/pathology; Swimming/psychology; Time Factors

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Database: MEDLINE Main subject: Piracetam / Status Epilepticus / Behavior, Animal / Brain Damage, Chronic / Anticonvulsants Type of study: Etiology_studies / Guideline / Prognostic_studies Limits: Animals Language: En Year: 2007 Type: Article

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