Generation of a homology model of the human histamine H(3) receptor for ligand docking and pharmacophore-based screening.

Schlegel, Birgit; Laggner, Christian; Meier, Rene; Langer, Thierry; Schnell, David; Seifert, Roland; Stark, Holger; Höltje, Hans-Dieter; Sippl, Wolfgang

Schlegel, Birgit; Laggner, Christian; Meier, Rene; Langer, Thierry; Schnell, David; Seifert, Roland; Stark, Holger; Höltje, Hans-Dieter; Sippl, Wolfgang.

Affiliation

Schlegel B; Institute of Pharmaceutical Chemistry, Heinrich-Heine-Universität Düsseldorf, Universitätsstr 1, 40197, Dusseldorf, Germany.

J Comput Aided Mol Des ; 21(8): 437-53, 2007 Aug.

Article in En | MEDLINE | ID: mdl-17668276

Subject(s)

Computer Simulation; Drug Design; Histamine Antagonists/chemistry; Histamine Antagonists/pharmacology; Receptors, Histamine H3/chemistry; Animals; Binding Sites; Cattle; Drug Evaluation, Preclinical; Humans; Ligands; Methylhistamines/chemistry; Methylhistamines/metabolism; Models, Molecular; Receptors, Histamine H3/metabolism; Thermodynamics; User-Computer Interface

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Database: MEDLINE Main subject: Computer Simulation / Drug Design / Receptors, Histamine H3 / Histamine Antagonists Type of study: Diagnostic_studies / Screening_studies Limits: Animals / Humans Language: En Year: 2007 Type: Article

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