Sequential evaluation of thiopurine methyltransferase, inosine triphosphate pyrophosphatase, and HPRT1 genes polymorphisms to explain thiopurines' toxicity and efficacy.

Palmieri, O; Latiano, A; Bossa, F; Vecchi, M; D'Incà, R; Guagnozzi, D; Tonelli, F; Cucchiara, S; Valvano, M R; Latiano, T; Andriulli, A; Annese, V

Palmieri, O; Latiano, A; Bossa, F; Vecchi, M; D'Incà, R; Guagnozzi, D; Tonelli, F; Cucchiara, S; Valvano, M R; Latiano, T; Andriulli, A; Annese, V.

Affiliation

Palmieri O; U.O. Gastroenterologia ed Endoscopia Digestiva, Ospedale IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo (Fg), Italy.

Aliment Pharmacol Ther ; 26(5): 737-45, 2007 Sep 01.

Article in En | MEDLINE | ID: mdl-17697207

Subject(s)

Gastrointestinal Agents/administration & dosage; Inflammatory Bowel Diseases/drug therapy; Methyltransferases/adverse effects; Polymorphism, Genetic; Pyrophosphatases/adverse effects; Adult; Female; Gastrointestinal Agents/adverse effects; Gastrointestinal Agents/pharmacokinetics; Genotype; Humans; Leukopenia/chemically induced; Male; Methyltransferases/metabolism; Middle Aged; Treatment Outcome; Inosine Triphosphatase

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Database: MEDLINE Main subject: Polymorphism, Genetic / Pyrophosphatases / Gastrointestinal Agents / Inflammatory Bowel Diseases / Methyltransferases Limits: Adult / Female / Humans / Male / Middle aged Language: En Year: 2007 Type: Article

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