Protective effect of Amomi semen extract on alloxan-induced pancreatic beta-cell damage.
Phytother Res
; 22(1): 86-90, 2008 Jan.
Article
in En
| MEDLINE
| ID: mdl-17724760
ABSTRACT
The protective effect of Amomi semen extract (ASE) on alloxan-induced pancreatic beta-cell damage was investigated in HIT T-15 cells, a Syrian hamster pancreatic beta-cell line. Alloxan caused pancreatic beta-cell damage through the generation of reactive oxygen species (ROS), the elevation of cytosolic free Ca2+, DNA fragmentation and the decrease of cellular NAD+ and ATP levels. All these effects of alloxan were significantly prevented by pretreatment with a water-soluble extract of Amomi semen. Pretreatment with ASE in pancreatic islets isolated from mice, also significantly abolished the inhibition of glucose-stimulated insulin secretion by alloxan. The results of this study provide evidence that ASE may have a protective activity on alloxan-induced beta-cell damage, and that the protective effect is primarily due to the inhibition of ROS generation by alloxan.
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Database:
MEDLINE
Main subject:
Plant Extracts
/
Amomum
/
Alloxan
/
Insulin-Secreting Cells
Limits:
Animals
Language:
En
Year:
2008
Type:
Article